Is The Combination Of Ibuprofen And Caffeine Effective For The Treatment Of A Tension
J Fam Pract
Nicole Sparano, Pharm.D, BCPSWyoming Valley Family Practice Residency, Kingston, Pennsylvania, Wilkes University Wilkes-Barre, Pennsylvania E-mail:
Diamond S, Balm TK, Freitag FG. Ibuprofen plus caffeine in the treatment of tension-type headache. Clin Pharmacol Ther 2000; 68:312-19.
BACKGROUND: Studies have shown the effectiveness of the addition of caffeine to ibuprofen for acute pain. However, this combination for use in tension-type headaches has been less well studied because of insensitive methods for evaluating this type of headache pain. The purpose of this study was to evaluate the efficacy of ibuprofen plus caffeine for the treatment of tension-type headaches and to establish a sensitive method to compare the combination versus either agent alone.
POPULATION STUDIED: This multicenter study reported on 301 evaluable patients with a history of tension-type headaches as defined by the International Headache Society. The mean age of the patients was 37 years. Patients were included who had 3 to 15 tension-type headaches every month for the past year and were responsive to over-the-counter analgesics at least 75% of the time. Patients who also suffered from migraines were able to participate if the type of headache pain could be differentiated by the quality of the pain or associated symptoms. Patients were excluded if they were allergic to the study drugs or had a comorbid illness that could potentially affect the pharmacokinetics of the study medication.
Single Dose Oral Ibuprofen Plus Caffeine For Acute Postoperative Pain In Adults
Acute pain is often felt soon after injury. Most people who have surgery have moderate or severe pain afterwards. Painkillers are tested in people with pain, often following the removal of wisdom teeth. This pain is usually treated with painkillers taken by mouth. Results can be applied to other forms of acute pain.
A series of Cochrane reviews looks at how good painkillers are. We know that in some circumstances combining different painkillers in the same tablet or taking separate tablets at the same time gives good pain relief to more people than either painkiller alone. This is particularly true using a combination of two painkillers that work by different mechanisms. This review looked at how good the combination of ibuprofen and caffeine was in relieving moderate or severe pain after surgery.
We searched up to 1 February 2015 and found four studies with a maximum of 334 participants with information for analysis. Ibuprofen 200 mg plus caffeine 100 mg provided effective pain relief for 6 in 10 participants, compared with 1 in 10 participants with placebo .
Adverse events occurred at similar rates with the ibuprofen plus caffeine combination and placebo in these single dose studies . No serious adverse events or withdrawals due to adverse events occurred with the combination.
Some people may get good levels of pain relief with a lower dose of ibuprofen when the ibuprofen is combined with caffeine.
Adverse event rates were low, and no sensible analysis was possible.
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How Should I Use This Medication
The recommended adult dose of ibuprofen is 200;mg to 400;mg every 6 to 8 hours as required.;Extended-release tablets should be taken as 1 tablet every 12;hours. The maximum daily dose is 1,200;mg. Ibuprofen available without a prescription should not be taken for more than 3 consecutive days for a fever or 5;consecutive days for pain unless advised by your doctor. The lowest dose for the shortest period of time should be used to reduce the risk of side effects.
The dose of ibuprofen for children is based on body weight and age. It should be given every 6 to 8 hours. Ask your doctor or pharmacist for specific dosing information. Use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons.
Take ibuprofen with food or milk to minimize side effects such as heartburn and stomach upset. The suspension form should be shaken well before using.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications.;If your doctor has recommended a dose different from the ones listed here,;do not change the way that you are taking the medication without consulting your doctor.
Store this medication at room temperature, protect it from heat and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
What Otc Pain Relievers Are Easiest On Kidneys
Acetaminophen is the OTC pain reliever of choice for people with kidney disease because ibuprofen and naproxen can decrease kidney function and aspirin is associated with bleeding complications. Even so, if your kidney function is impaired, use acetaminophen sparingly and under the care and supervision of your healthcare provider.
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How Should I Take Acetaminophen And Caffeine
Use this medication exactly as directed on the label, or as prescribed by your doctor.
Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.
The orally disintegrating tablet should be placed directly on the tongue. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.
Acetaminophen may cause false urine glucose test results. Talk to your doctor if you have diabetes and you notice changes in glucose test results while taking acetaminophen and caffeine.
Store at room temperature away from heat and moisture.
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What Other Drugs Could Interact With This Medication
There may be an interaction between ibuprofen and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist.;Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them.;Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication.;Tell your doctor or prescriber about all prescription, over-the-counter , and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 2021. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Motrin
Who Should Not Take This Medication
Do not use this medication if you:
- are allergic to ibuprofen or any ingredients of this medication
- are allergic to other NSAIDs
- are currently taking other NSAIDs
- are pregnant
- are dehydrated due to vomiting, diarrhea, or lack of fluid intake
- have an active peptic ulcer, a history of recurring ulcers, or an active inflammatory disease of the digestive system
- have nasal polyps, or have had asthma, an allergic reaction or allergic-type reaction to ASA or any other NSAIDs
- have severely reduced kidney function or kidney disease
- have severely reduced liver function or liver disease
- have high levels of potassium in the blood
- have systemic lupus erythematosus
- have inflammatory bowel disease
- are having heart surgery in the near future or have recently had heart surgery
Do not give this medication to children who have kidney disease or have suffered significant fluid loss.
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What Is The Ingredients In Midol
What is the ingredients in midol
- What is the ingredients in midol?
- Midol Composition. Acetaminophen is a pain reliever and a fever reducer. Diphenhydramine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in the body. Diphenhydramine prevents sneezing, it
- What are the ingredients of midol?
- Acetaminophen 500 mg Caffeine 60 mg Pyrilamine Maleate 15mg
New Medicines That Fightmigraines Look Familiar
NEW ADS FROM Motrin Migraine thisweek tout the drug “for people who don’t fool around with pain.” MotrinMigraine, the ads promise, “kicks butt.”
This may sound like welcome news to the country’s estimated 28 millionmigraine sufferers. But Motrin Migraine is actually a marketing, not amedical, breakthrough. Motrin Migraine, along with the other newover-the-counter migraine drugs Advil Migraine and Excedrin Migraine, areexactly the same pill as the original versions, with the same ingredientsin the same dose. They are simply in a different package.
Motrin Migraine contains 200 milligrams of ibuprofen, just like regularMotrin. Advil Migraine also contains 200 milligrams of ibuprofen, just likeregular Advil. And Excedrin Migraine contains the same combination ofaspirin, acetaminophen and caffeine found in extra-strength Excedrin.
The only difference is that the Food and Drug Administration now allowsthe three pain relievers to claim they ease the pain of migraine headache,in addition to other aches and pains.
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What Happens If I Overdose
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can damage your liver or cause death.
The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.
Does Ibuprofen Cause Rebound Headaches
Reboundheadachesrebound headacheibuprofenmigrainecause rebound headaches
In this way, what can I take for rebound headaches?
- Nonsteroidal anti-inflammatory drugs , such as ibuprofen and naproxen.
- Sedatives for sleep.
- Codeine and prescription narcotics.
- Over-the-counter combination headache remedies that have caffeine
can ibuprofen give you a headache? Pain relievers such as ibuprofen and naproxen sodium have a low risk of contributing to medication overuse headaches. Combination pain relievers. Over-the-counter pain relievers that combine caffeine, aspirin and acetaminophen are common culprits.
Similarly, how long do rebound headaches last?
Rebound headaches generally have other characteristics. They begin three to four hours after a drug wears off. They may occur daily or almost daily, and last from about six hours to a full day.
Does ibuprofen have a rebound effect?
Ibuprofen, the active ingredient in Advil, is among the drugs that are known to trigger rebound headaches when taken in a way that’s off-label, such as in larger doses or more often than is recommended on the label.
What Is Motrin Ib
Motrin IB is a nonsteroidal anti-inflammatory drug . Ibuprofen works by reducing hormones that cause inflammation and pain in the body.
Motrin IB is used in adults and children who are at least 12 years old.
Acetaminophen And Caffeine Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction:hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking acetaminophen and caffeine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.
Stop using acetaminophen and caffeine and call your doctor at once if you have:
low fever with nausea, stomach pain, and loss of appetite;
dark urine, clay-colored stools; or
Common side effects may include:
sleep problems ; or
feeling nervous, irritable, or jittery.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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What Otc Pain Relievers Are Safe To Take Together
You shouldn’t take more than one drug from a class at a time because it increases your risk of side effects or overdose. That means it’s NOT safe to combine NSAIDsaspirin, ibuprofen, naproxen, or prescription NSAIDs. Because acetaminophen has a different mechanism of action, it can be safely taken with NSAIDs.
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Are There Any Other Precautions Or Warnings For This Medication
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
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Do You Need To See A Doctor
If your menstrual cramps are unusual or severe, or if they last more than a few days, you may want to see your doctor. Painful period cramping is treatable, so anytime you’re worried about your symptoms, it’s a good idea to talk to your doctor.
Your doctor may perform a pelvic exam to make sure everything is normal. They may also ask you questions about your menstrual period history, suggest lifestyle modifications, or even recommend and prescribe medicines that may help relieve your painful periods.
Who Can And Cant Take Advil
Some brands of Advil-Migraine tablets, capsules and syrup contain aspartame, colors , gelatin, glucose, lactose, sodium, sorbitol, soya or sucrose, so they may be unsuitable for some people.
Dont take Advil-Migraine by mouth if you:
- have had an allergic reaction to Advil-Migraine or any other medicines in the past
- have previously had a reaction, such as asthma, a raised, itchy red rash , swelling underneath your skin or swelling of the inside of your nose
- have taken aspirin or any other nonsteroidal anti-inflammatory drug
- have asthma or another allergic illness
- are trying to get pregnant, are already pregnant or if youre breastfeeding
To make sure Advil-Migraine is safe for you, tell your doctor or pharmacist if you have:
- had bleeding in your stomach, a stomach ulcer, or a perforation in your stomach
- a health problem that means you have an increased chance of bleeding
- liver problems, such as liver fibrosis, cirrhosis or liver failure
- heart disease or severe heart failure
- kidney failure
- Crohns disease or ulcerative colitis
- chickenpox or shingles taking Advil-Migraine can increase the chance of certain infections and skin reactions
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Are Any Otc Pain Relievers Safe To Take During Pregnancy
Acetaminophen is considered the safest OTC pain reliever to take while you’re pregnant, but only for short-term use. According to a study by the Centers for Disease Control and Prevention, birth defects were less common when acetaminophen was used during pregnancy than when NSAIDs or opioids were taken.
As with anything you take during pregnancy, be sure to talk to your obstetrician before using it.
How To Cope With Side Effects
What to do about:
- indigestion stop taking Advil-Migraine and see your doctor as soon as possible. If you need something to ease the discomfort, try taking an antacid, but dont put off going to the doctor.
- feeling sick stick to simple meals. Dont eat rich or spicy food
- vomiting have small, frequent sips of water. It may also help to take oral rehydration solutions like Pedialyte you can buy from a pharmacy or supermarket to prevent dehydration. Dont take any other medicines to treat vomiting without speaking to a pharmacist or doctor.
- wind try not to eat foods that cause wind . Eat smaller meals, eat and drink slowly, and exercise regularly. There are pharmacy medicines that can also help, such as charcoal tablets or simethicone.
- your skin being sensitive to sunlight stay out of bright sun and use a high factor sun cream even on cloudy days. Dont use a sun lamp or sun beds.
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