Motor Benefit Of Caffeine In Pd Patients And Pd Models
The symptomatic effect of caffeine in PD was first tested in 1970s , but has been revisited by several clinical studies recently. The motor benefit of caffeine were documented in a pilot open-label, 6-week dose-escalation study and a 6-week randomized controlled trial of caffeine involving 61 PD patients . These clinical studies suggest that caffeine improved objective motor deficits in PD with the reduced total Unified PD Rating Scale score and the objective motor component. Furthermore, coffee consumption is associated with the reduced hazard ratio for the development of dyskinesia compared with subjects who consumed < 112 mg/day in the Comparison of the Agonist Pramipexole with Levodopa on Motor Complications of Parkinsons Disease and CALM Cohort extension studies . Based on these positive findings, caffeine was recently investigated for motor and disease-modification involving 121 PD patients PD in a phase 3, 5-years , two-arm, double-blind RCT, with a primary outcome focused on motor symptoms and disease-modification as a secondary outcome1. Unfortunately, with the primary outcome analysis after 6 months demonstrating no significant symptomatic benefit of caffeine , the study was terminated earlier than the planned.
Caffeine From Two To Four Daily Cups Of Coffee May Reduce Parkinson’s Disease Symptoms
Should doctors start prescribing coffee?
In the latest study to tie coffee to health benefits, new research finds a daily caffeine boost may ease symptoms of Parkinson’s disease in sufferers.
Parkinson’s is a degenerative brain disease that causes tremors, difficulty with walking, movement and coordination. The condition most commonly develops in adults over 50, and occurs when nerve cells in the brain that make the muscle-controlling neurotransmitter dopamine are slowly destroyed, leading to loss in muscle function. The cause of the disease remains unknown.
The study, published August 1 in the online issue of Neurology, tracked 61 people with Parkinson’s who were exhibiting symptoms of daytime sleepiness. Participants were assigned to receive either a placebo pill twice per day or a 100 milligram-caffeine pill twice per day for three weeks. After three weeks, those in the caffeine group were given a 200 milligram caffeine pill twice per day, about the caffeine equivalent found in two to four cups of coffee.
Six weeks into the study, people taking the caffeine pills averaged a five-point improvement on a ratings scale of Parkinson’s symptom severity compared to those who took placebos. Researchers called this a modest improvement, but one that might provide benefits to people with the disease.
Oddly enough, caffeine did not appear to help improve the patients’ daytime sleepiness problems.
Comparison Between Coffee And Non
Of the 284 de novo PD patients enrolled , a total of 204 patients and 80 patients were categorized as coffee drinkers and non-coffee drinkers , respectively. The coffee drinker group comprised current coffee drinkers and those who have had coffee in the past but have now stopped. Most of the patients who quit drinking coffee had a history of coffee drinking for more than 10years. As shown in Table , intergroup comparisons revealed that coffee drinkers were younger, included more men, younger in age at cardinal motor symptom onset, and reported more years in formal education than the non-coffee drinkers. When comparing motor- and ADL-related scores, coffee drinkers had significantly lower UPDRS motor scores as well as tremor , bradykinesia , and gait and posture scores than non-coffee drinkers. When the tremor was divided into rest and action tremors, only rest tremor showed a significant difference. Furthermore, the univariate analysis revealed that coffee drinkers had significantly lower tremor scores than non-coffee drinkers. However, PIGD and AR scores were not significantly different between the two groups. When comparing non-motor scores, we found that coffee drinkers had higher MMSE , but lower BDI and total NMSS scores than non-coffee drinkers.
Table 1 Demographics and clinical characteristics of patients with Parkinsons disease
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Coffee Smoking And Aspirin Influence Parkinson’s Disease Onset
The comprehensive assessment involved a total of 35,963 patients in the United States with idiopathic PD, the most common form of the neurodegenerative condition, which hinders the brain’s ability to control movement.
“Given our own data and the previously published protective effects of smoking, caffeine, anti-inflammatory drugs, and the detrimental effects of pesticide exposure on PD risk, we set out to investigate these factors in detail,” study investigator Joanne Trinh, PhD, group leader, Institute of Neurogenetics, University of Lübeck in Germany, told Medscape Medical News.
She noted “it is important to understand external factors that can help delay onset and slow down progression.”
The research was posted online November 9 in medRxiv and has not been peer reviewed.
A Cup Of Joe May Help Some Parkinsons Disease Symptoms
The American Academy of Neurology, an association of more than 25,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimers disease, stroke, migraine, multiple sclerosis, brain injury, Parkinsons disease and epilepsy.For more information about the American Academy of Neurology, visit http://www.aan.com or find us on , , and .
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May Protect Your Liver
Your liver is an amazing organ that carries out hundreds of important functions.
Several common diseases primarily affect the liver, including hepatitis, fatty liver disease and many others.
Many of these conditions can lead to cirrhosis, in which your liver is largely replaced by scar tissue.
Interestingly, coffee may protect against cirrhosis people who drink 4 or more cups per day have up to an 80% lower risk .
Coffee drinkers have a much lower risk of cirrhosis, which can be caused by several diseases that affect the liver.
The Pencil Grip Heavyweight Mechanical Pencil Set Tpg
Make your loved one’s day-to-day a little easier, starting with their writing utensils.
Accomplishing tasks can take longer due to slowness of movements, explains Dr. Nwabuobi. Writing and performing other fine motor tasks such as putting on jewelry or shaving can become more laborious due to tremor. Weighted pens are a great way for those with Parkinsons to cut down on tremors and gain better control of their hand while writing, making the process easier and handwriting more readable.
This weighted pen from The Pencil Grip is said to help people develop better motor control and build up strength through regular use. It weighs four ounces to add a nice level of heftiness and bring a smooth finish to any writing efforts.
Upon diagnosis, Dr. Nwabuobi advises all her patients to become physically active and start a fitness regimen. Ideally, exercise should include stretching, aerobic activity, and resistance training. I tell patients to do what they love as long as they are increasing their heart rate and breaking a sweat. This can include speed walking, dancing, yoga, swimming, cycling, boxing, pilates, etc., she adds. An apple watch is a great way for Parkinsons patients to not only keep track of their exercise habits, but all their daily movements. It also monitors heart rates and irregular irregular heart rhythms. Honestly, theres nothing like a new, shiny device meant to encourage physical activity to make you get up and move.
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Caffeine May Influence Pd Pathology By Modulating Gut Microbiota
The gut microbiota in the human gastrointestinal tract is estimated to contain 10 times more microbial cells than human cells, and approximately 100200-times more protein coding genes than the human genome . The gut microbiota critically influence various aspects of human biology, including the absorption and metabolism of nutrients, vitamins, medications, and toxic compounds the development and differentiation of the intestinal epithelium and immune system, the maintenance of tissue homeostasis, and the prevention of pathogens invasion . The gut microbiota also plays an important role in gut-brain communication, and the neuroimmune system to maintain brain homeostasis, thus influencing brain function and behavior . In healthy subjects, the intestinal microbiota is generally stable over time, but compositional changes might occur following antibiotic usage or dietary modifications .
Coffee Contains A Lot Of Antioxidants
Coffee is a goldmine of antioxidants, and is also rich in potassium, magnesium, manganese, chromium, probiotics, vitamins and tocopherols. In fact, one of the surprising results from a study conducted in the United States a few years ago was that we get more antioxidants from this drink than from fruits and vegetables. In addition, we generally consume more coffee than fruits.
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Caffeine As A Biomarker For Parkinson’s Disease
Researchers at Juntendo University report in Neurology the potential use of blood levels of caffeine and its byproducts as biomarkers for Parkinson’s disease. The finding is promising for the development of a method enabling early identification of the disease.
Parkinson’s disease is a degenerative disorder of the central nervous system, affecting the latter’s motor systemthe part controlling bodily motion. Its symptoms include shaking, rigidity and difficulty with walking. There is evidence that daily caffeine consumption reduces the risk of developing Parkinson’s. Now, a team of researchers led by Nobutaka Hattori from Juntendo University School of Medicine have studied how traces of caffeine in the blood, after drinking coffee, can be indicative of Parkinson’s disease. The researchers found that caffeine levels are significantly lower in patients with the disease caffeine concentrations could therefore be used as an indicator of Parkinson’s, particularly in its early stages.
The researchers studied a group of 139 people, both men and women, with and without Parkinson’s disease. Each person drank between 0 and 5 cups of coffee per day . Then, they checked the participants’ blood serum for traces of caffeine and its 11 so-called downstream metabolitessmall molecules produced during caffeine-induced metabolic processes in the human body.
Whole Coffee Fruit Concentrate
Hi I’ve just been watching a series of episodes on Alzheimer’s and came across the following article which claims Whole Coffee Fruit Concentrate increases BDNF by up to 143%. Has anyone heard of this or know where I can source it? I’ve tried iHerb, Amazon, eBay, and a general google search.
I have not seen it elsewhere. But I am sure Google is your friend. Why not ask
Thanks. Just looked and its currently unavailable, but this product has only 1/12th Coffee Fruit Concentrate
I watched the same series, always impressed with Dr Perlmutter and his teachings. I have been looking into the coffee fruit concentrate and I think it depends on how you phrase the search. Coffee fruit concentrate or coffee berry are two options. I may try this in the near future since I know I have some dementia.
Have bought the Amazon Hawaii one but still not sure that its the right one. Many thanks.
Im going to look into the Futureceuticals one next week. Its the same site as coffeeberry.com.
I’ve sent an enquiry on Futureceuticals Contact Us link so am waiting on their reply. Swansons are out of stock. It is not easy to find this product. Plenty of links for whole coffee bean concentrate but I understand that this stuff is only the coffee fruit.
Organic green coffee bean extract, bulk powder, Amazon:
Thanks Reedboat2. Looked at the ingredients and I’m not sure its the coffee fruit concentrate.
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Mechanisms Remain A Mystery
Commenting on the findings for Medscape Medical News, Clemens Scherzer, MD, professor of neurology, Harvard Medical School in Boston, said, “we have known for some time that coffee drinking and smoking are strongly associated with reduced risk of developing PD, although the exact mechanisms and the exact chemicals at play remain mysterious.”
Overall, “the data did not provide a clear answer” on aspirin’s possible effects, said Scherzer, who is also director, American Parkinson Disease Association Center for Advanced Research at Brigham & Women’s Hospital, attributing the uncertainty to the type of analysis, confounding variables, and the study’s retrospective design.
“Instead,” he added, “the results suggest that this might be a clue worthy of further investigation and clarification.”
While noting the study’s observations are exploratory and preliminary, Scherzer, who was not involved in the research, noted “coffee lovers, however, can feel good about this study. Risk is reduced and Parkinson’s disease might start later in people who drink coffee.”
Also commenting on the research, Andrew Siderowf, MD, professor of neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, who was not involved in the study, urged caution in interpreting the findings.
The researchers, Scherzer, and Siderowf report no relevant disclosures.
medRxiv. Published online November 9, 2021. Full text
Susan Kreimer is a New York-based freelance health journalist.
You’re Not As Likely To Suffer A Stroke
For women, drinking at least one cup of coffee a day is associated withlowered stroke risk, which is the fourth leading cause of female deaths.
5 Heart-Healthy Food Swaps
When it comes to your heart health, it’s the little, everyday choices you make that can have the biggest impact on your future well-being. Isatu Isuk, a dietitian at The Johns Hopkins Hospital, suggests five simple adjustments you can make to help boost your heart health.
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Coffee May Drastically Lower Your Risk Of Type 2 Diabetes
Type 2 diabetes is a lifestyle-related disease that has reached epidemic proportions. It has increased 10-fold in a few decades and now afflicts about 300 million people.
This disease is characterized by high blood glucose levels due to insulin resistance or an inability to produce insulin.
In observational studies, coffee has been repeatedly associated with a lower risk of type 2 diabetes. The reduction in risk ranges from 23% all the way up to 67% .
A massive review article looked at 18 studies with a total of 457,922 participants. Each additional cup of coffee per day lowered the risk of type 2 diabetes by 7%. The more coffee people drank, the lower their risk was .
Drinking coffee is associated with a drastically reduced risk of type 2 diabetes. People who drink several cups per day are the least likely to develop diabetes.
Cubii Pro Seated Under Desk Elliptical Machine
While there is no cure for Parkinsons, a combination of exercise and the proper pharmacological therapy can alleviate symptoms, says Dr. Nwabuobi. Animal data suggests that exercise affects dopaminergic neurotransmission and neuroplasticity. Clinically, it helps patients maintain their balance, mobility and activities of daily living, she explains further. The Cubii Pro Seated Elliptical Machine is a great way to get in physical activity throughout the day, whether doing work at your desk or lounging on the couch. Its able to sync with smartphones and fitness trackers to keep an accurate record of your pedaled distance, calories burned, and more.
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Is Coffee Good For You How Much Should We Drink
For many of us, coffee is a stimulating elixir that we drink every morning, and whose intoxicating scent surrounds and strengthens us. Who doesnt love a good cup for breakfast or after a big meal? We all do, but Im sure you have a lot of questions about whether its actually good for you, and how much of it you should drink per day. So today we will answer the big question: Is coffee good for you?
Hyde Lane Sherpa Heated Blanket
Parkinsons can cause some people to become more sensitive to the cold, which means a heated blanket can come in handyno matter what time of the year. This 100% polyester electric throw from Hyde Lane is thick and soft, which makes it the perfect snuggle buddy. And with a power cord over six feet, you can position yourself comfortably without worrying about unplugging at any point. It also has three different heating levels that help relieve body aches and pains, making it easier to relax and hopefully, fall asleep.
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Levinsohn Textile Company Satin Charmeuse Silky Sheet Set Collection
Parkinsons deeply affects peoples functionality and mobility. This can cause poor sleeping patterns because of the difficulty people have turning in bed. Dr. Nwabuobi says silk sheets can make readjusting at night easier for people with Parkinsons. While silk is nice, it can also be terribly expensive. But these satin silk sheets do the job just fine and are a steal in comparison. These sheets are lightweight, breathable, and soft to the touch. Available in red, black, grey, and ivory, these sheets will add a nice pop of color to the bedroom and make anyone excited to fall asleep.
Allbirds has a great selection of slip-on shoes for both men and women. Their Tree Loungers, made from eucalyptus tree fibers, are especially nice. In addition to being conveniently laceless, theyre also lightweight and breathable, making it even easier for people with Parkinsons to slip them on. With their low-density soles, the Tree Loungers mimic the shape of your feet and add little weight, ensuring your mobility isnt hindered. Considering tremors are a common symptom of the condition, putting on shoes can be a complicated and time consuming task. But these shoes make the process simpleand it doesnt hurt that they help the environment by emitting less carbon than petroleum-based foam shoes.
May Lower Your Risk Of Type 2 Diabetes
Type 2 diabetes is a major health problem, currently affecting millions of people worldwide.
Its characterized by elevated blood sugar levels caused by insulin resistance or a reduced ability to secrete insulin.
For some reason, coffee drinkers have a significantly reduced risk of type 2 diabetes.
Studies observe that people who drink the most coffee have a 2350% lower risk of getting this disease. One study showed a reduction as high as 67% (22,
Several observational studies show that coffee drinkers have a much lower risk of type 2 diabetes, a serious condition that affects millions of people worldwide.
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