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Does Excedrin Migraine Contain Caffeine

How Excedrin Migraine Works

Can’t find your Excedrin Migraine pills at the pharmacy? Here’s why

Excedrin Migraine is a combination of three medications that work together to relieve minor aches and pains in different ways.

  • Acetaminophen is an analgesic. It’s not fully known how acetaminophen works, but it’s thought to work in your brain to relieve pain.
  • Aspirin is a non-steroidal inflammatory drug that stops the production of certain substances in your body that cause pain and inflammation .
  • Caffeine is an adenosine antagonist. It blocks the activity of a natural chemical in the body called adenosine that’s higher during migraine attacks. Blocking adenosine has been shown to help lower the sensation of pain and relieve migraine symptoms. It has also been shown to improve the effects of acetaminophen and aspirin, so you don’t need to take as much of these two pain medications.

Caffeines Effects On Pain And Non

There is evidence that caffeine may reduce pain sensation through its effects on adenosine receptors . The antinociceptive effects of caffeine may be explained by an inhibition of cyclooxygenase activity as well as adenosine receptor antagonism. Caffeine acts not only by central blocking of adenosine receptors, which affects pain signaling, but also by blocking peripheral adenosine receptors on sensory afferents . It was demonstrated that a 200 mg caffeine dose can inhibit the analgesic effects of transcutaneous electrical nerve stimulation . Caffeine combined with a standard dose of analgesics led to an increased proportion of individuals with a satisfactory level of pain relief . Laska et al. found that, in combination with paracetamol or aspirin, caffeine reduced the amount of analgesic needed to reach the same effect by approximately 40% . Other clinical effects in these patients may be linked with the promotion of the absorption of analgesics by rapid lowering of gastric pH. Nevertheless, meta-analyses of caffeine combined with ibuprofen, paracetamol, or acetylic acid found only weak adjuvant effects in patients with postoperative pain .

Does Excedrin Increase Heart Rate

4.8/5canheart beatExcedrindetail here

If you have any of these side effects, stop taking Excedrin and call your doctor right away:

  • Rash or hives.
  • Ringing in your ears.
  • Swelling of the face, eyes, lips, tongue, or throat.

Also Know, does Excedrin raise your blood pressure? Experts believe that acetaminophen is safe for people with high blood pressure. Long-term use of acetaminophen in high doses — especially when combined with caffeine or codeine can cause kidney disease. Acetaminophen doesn’t reduce swelling, like aspirin and other NSAIDs do.

Just so, what drug makes your heart beat faster?

Cocaine is a potent stimulant drug. It creates a variety of effects on the body. For example, it stimulates the central nervous system, causing a euphoric high. It also causes blood pressure and heart rate to increase, and it disrupts the heart’s electrical signals.

Why was Excedrin Migraine taken off the market?

Excedrin Extra Strength and Excedrin Migraine, in both caplets and gel-tablets, are temporarily off the shelves. GlaxoSmithKline, which manufacturers the popular painkillers, pulled the two drugs and temporarily suspended their production after finding irregularities at the plants that make them.

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Harm To Unborn Babies

  • Risk factors: Currently pregnant

Excedrin Migraine can raise the risk of heart and kidney problems in an unborn baby and complications during delivery if you take it after 20 weeks of pregnancy. Talk with your provider or pharmacist about alternative medications that are safe and will work best for you while you’re pregnant.

Excedrin Serious Side Effects

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Get emergency medical help if you have any of these signs of an allergic reaction to Excedrin: hives difficulty breathing swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking Excedrin and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

Stop using Excedrin and call your doctor at once if you have:

  • severe anxiety, agitation, confusion, panic
  • easy bruising or bleeding
  • a light-headed feeling, like you might pass out
  • if you feel very thirsty or hot, are unable to urinate, and have heavy sweating or hot and dry skin
  • symptoms of stomach bleedingbloody or tarry stools, coughing up blood or vomit that looks like coffee grounds
  • high potassiumslow heart rate, weak pulse, muscle weakness, tingly feeling or
  • liver problemsnausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice .

Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Other side effects of Exedrin

  • Belly pain or heartburn.
  • Upset stomach.

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How Much Aspirin Is In Excedrin Pm

4.4/5more about it

Excedrin PM is an over the counter medication used to treat headaches, minor aches and pain, and difficulty sleeping due to minor pain. It is a single product containing 3 ingredients: acetaminophen, aspirin, and diphenhydramine.

One may also ask, is Excedrin PM the same as Tylenol PM? Tylenol PM is the top-selling nighttime painkiller, ahead of Excedrin PM and Pfizer Inc’s Advil PM, which combines the same sleep aid with ibuprofen.

Secondly, why was Excedrin PM taken off the market?

Store shelves are empty because Novartis voluntarily pulled Excedrin because the FDA says there was a risk that it might be contaminated with opiate prescription drugs like morphine, which were made in the same plant.

Is it safe to take Excedrin PM every night?

No, Excedrin®PM Headache is indicated for the temporary relief of occasional nighttime headaches and minor aches and pains with accompanying sleeplessness. When using this product, drowsiness will occur. Do not drive a motor vehicle or operate machinery while using this product.

See Your Primary Care Doctor

It’s best to come up with a plan with your primary care doctor or headache specialist concerning which over-the-counter medication you may take if you develop a headache. This is because even though Tylenol, Excedrin, and NSAIDs are available without a prescription, they are not safe for everyone.

While not an exhaustive review, here are some examples of the concerns associated with these over-the-counter medications.

NSAIDs : NSAIDs can cause stomach irritation and bleed so should not be used by people on blood-thinning medications or by people with a history of stomach ulcers.

Moreover, people with certain medical problems should either not take NSAIDs or should be very closely monitored by their healthcare provider while taking one.

Aspirin or aspirin-containing products , should never be given to children, as they can increase a child’s risk for developing a serious illness called Reye’s syndrome.

Tylenol : Many over-the-counter medications contain Tylenol , like cold medicines and of course, Excedrin. With that, a person can overdose on Tylenol unintentionally, and this can lead to liver failure.

All Over-the-Counter Medications:Over-the-counter medications may interact with your prescription medications. This is why it’s essential to inform your healthcare provider of all the medications you are taking, including any vitamins or supplements.

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Does Excedrin Migraine Work

Excedrin Migraine is a brand of pain relieving medication that contains three active ingredients acetaminophen, aspirin and caffeine. These drugs combined, work together to help relieve pain. Acetaminophen acts as a pain reliever and fever reducer. Aspirin helps reduce pain, inflammation, and swelling. Caffeine helps increase the effects of aspirin and acetaminophen.

How fast Excedrin migraine works depends on a number of factors including body mass, age, genetics and metabolic rate. Acetaminophen is rapidly absorbed from the GI tract with peak plasma levels usually occurring at 2 hours and almost always by 4 hours. Acetaminophen for most people, has a half-life in the blood of 1.25 to 3 hours.

It is reported that the aspirin concentration in blood reaches its peak approximately 20 min after oral administration in healthy volunteers, but the absorption and bioavailability of aspirin in AMI may be quite different. The effects of caffeine the last ingredient can be felt as soon as 15 minutes after it is consumed. The level of caffeine in your blood peaks about one hour later and stays at this level for several hours for most people. Six hours after caffeine is consumed, half of it is still in your body. Evidence suggests that the use of combination analgesics such as Excedrin offers advantages in the treatment of headaches by targeting pain in more than one way.

What is migraine?

Signs and symptoms

Key Points About Caffeine And Migraines

Ask Dr. Nandi: Two Excedrin products are temporarily discontinued, company says
  • Caffeine affects pain.
  • Acute treatment of headaches with caffeine is sometimes effective but should be limited to not more than two days per week.
  • For people who experience migraine, caffeine taken three or more days per week, for whatever reason, may lead to dependency and increased migraine frequency.
  • For those who have frequent headaches, avoidance of all caffeine is ideal, and at least until improvement in headache frequency is seen.

Migraine patients often report that a strong cup of coffee can stop some attacks. This is not surprising to hear. Caffeine is a key active ingredient in many headache medications including ExcedrinTM, AnacinTM, MidolTM, Darvon CompoundTM, FioricetTM, and MigranalTM. Caffeine may aid in the bodys absorption of these medicines, but can caffeine itself relieve headaches? Few research studies have examined this question, but the answer appears to be yes. Caffeine can provide some headache relief. For example, one small controlled study found that caffeine was better than placebo, and as good as acetaminophen, in relieving tension-type headaches.

We dont fully understand the mechanisms underlying the different effects of caffeine on the brain. However, the specific targets of action of caffeine in the brain and nerves outside the brain are known.

Robert E. Shapiro, MD, Ph.D., Professor of Neurology, University of Vermont College of Medicine, Burlington, VT.

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How Does Caffeine Work On Migraine Pain

Caffeine affects a brain chemical called adenosine. Adenosine is found naturally in human cells. During a migraine attack, adenosine levels go up. This causes brain blood vessels to widen, reduce electrical activity, and change other body functions. Caffeine can block some of these actions, reducing head pain.1

Many studies have tried to reveal the secrets of how caffeine affects migraine attacks. One small study found caffeine worked better than a placebo and as well as acetaminophen for tension headaches.1

Ease Your Migraine Pain With Excedrin Migraine

Even though the cause of migraines is still largely unknown, and triggers vary from person to person, you should treat your migraines right away. One study found that a whopping 49 percent of migraine sufferers avoid or delay taking medications when they feel an attack coming on.7 Treating a migraine as soon as you feel pain leads to a better outcome.8 Be sure to talk to your doctor about your migraines and the best treatment plan for you.


  • Silberstein, Stephen D. Migraine – Neurologic Disorders. Merck Manuals Professional Edition,
  • Diener, H C, et al. The Fixed Combination of Acetylsalicylic Acid, Paracetamol and Caffeine Is More Effective than Single Substances and Dual Combination for the Treatment of Headache: a Multicentre, Randomized, Double-Blind, Single-Dose, Placebo-Controlled Parallel Group Study. Cephalalgia : an International Journal of Headache., U.S. National Library of Medicine, Oct. 2005,
  • Lipton, Richard B. Efficacy and Safety of Acetaminophen, Aspirin, and Caffeine in Alleviating Migraine Headache Pain. Archives of Neurology, American Medical Association, 1 Feb. 1998,
  • DeMaagd, George. The Pharmacological Management Of Migraine, Part 1: Overview and Abortive Therapy. Pharmacy and Therapeutics, MediMedia USA, Inc., July 2008,
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    What Are The Acute Treatment Options For Episodic Tension

    TTH can be treated with simple over-the-counter analgesics such as aspirin, acetaminophen , ibuprofen , naproxen sodium , and ketoprofen . OTC combination products that contain caffeine provide a useful alternative. Clinical trials demonstrate that the addition of caffeine to a simple analgesic significantly increases pain relief. This effect is referred to as the analgesic adjuvancy action of caffeine.

    When OTC medications do not provide adequate relief, prescription drugs can be tried. Nonsteroidal antiinflammatory agents such as naproxen sodium , 550 mg, or diflunisal , 500 mg, may succeed when OTC NSAIDs could not. Isometheptene-containing capsules are useful and produce few side effects. The butalbital-containing and caffeine-containing products are effective. Minor opioids, including codeine combinations , are also effective. Transnasal narcotics are useful for severe TTHs refractory to other treatments one must be concerned with the potential for overuse of these types of agents. In general, acute medications should not be used more than 2 or at most 3 days per week to avoid rebound headaches.

    What Drugs And Food Should I Avoid While Taking Excedrin

    Excedrin Migraine 300 Coated Caplets: Grocery ...

    Avoid drinking alcohol. It may increase your risk of liver damage or stomach bleeding.

    Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to acetaminophen or aspirin .

    Avoid coffee, tea, cola, energy drinks or other sources of caffeine while taking this medication. They can add to the side effects of the caffeine in the medication.

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    What Happens If I Overdose On Excedrin

    Early signs of acetaminophen overdose include loss of appetite, nausea, vomiting, sweating, or weakness. Later symptoms may include upper stomach pain, dark urine, and yellowing of your skin or eyes.

    Overdose symptoms may also include ringing in your ears, headache, diarrhea, hallucinations, fast or slow heart rate, or seizure .

    How To Use Excedrin Migraine

    See also Warning section.

    If you are taking the over-the-counter product to self-treat, read all directions on the product package before taking this medication. If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, take it as directed.

    Take this medication by mouth as directed by your doctor, or follow the product package directions. Drink a full glass of water with this medication unless your doctor directs you otherwise. If you are using the tablet form of this medication, do not lie down for at least 10 minutes after you have taken this drug. If upset stomach occurs, you may take it with food or milk.

    The dosage is based on your medical condition and response to treatment. Do not increase your dose or use this drug more often or for longer than directed. Do not use this product for pain lasting longer than 10 days or fever lasting more than 3 days. Use the smallest effective dose. Consult your doctor or pharmacist for more information.

    If you are taking this drug “as needed” , remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

    Consult your doctor if your condition persists or worsens .

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    Does Excedrin Keep You Awake

    Caffeine warning: The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.

    What Are The Side Effects

    When will Excedrin return to the shelves?

    Acetaminophen and aspirin can sometimes cause severe skin and/or allergic reactions. Avoid taking this medication if you are allergic to either, and seek immediate medical attention if you develop skin blisters, rash, hives, facial swelling, or trouble breathing.

    More common side effects, which typically go away once you stop taking the medication, include:

    • Diarrhea

    • Passing urine more often

    • Trouble sleeping

    The amount of caffeine in Excedrin Migraine is similar to that of a cup of coffee, so youll want to moderate your intake while taking this medication since too much caffeine can cause nervousness, irritability, and trouble sleeping.

    In addition, Excedrin Migraine contains an NSAID medication, which can cause stomach bleeding. Stop the medication and call your provider if you notice bloody or black stools or stomach pain that does not get better, or if you are vomiting blood or feeling faint. NSAIDs can also cause ringing in your ears or hearing loss. But this tends to be reversible once the medication is stopped.

    The medication also contains acetaminophen, which can be harmful to your liver. It is best not to exceed the maximum daily dosage, take additional acetaminophen products, or consume 3 or more alcoholic beverages a day while taking this medication.

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    Patient Fsa / Hsa Eligible Product

    This product is eligible for Flexible Spending Account and Health Savings Accounts

    Resulting from the CARES Act recently passed by congress, you can now use your FSA and HSA tax-preferred savings account to purchase certain OTC products such as Flonase, Nicorette, Nicoderm, Advil, Voltaren, and Denture Care Products. Your plan details may vary, so make sure to save your receipt and check with your benefits or health provider for eligibility. Please visit our page on Using My FSA/HSA.

    Migraine Medicines With Caffeine

    Many prescription and over-the-counter drugs that treat migraine have caffeine, such as:1,2

    • Anacin: caffeine and aspirin
    • Excedrin Migraine: caffeine, aspirin, and acetaminophen
    • Midol: caffeine, acetaminophen, and pyrilamine maleate
    • Norgesic: caffeine, aspirin, and orphenadrine citrate
    • Fioricet: caffeine, acetaminophen, and butalbital

    Many studies have found caffeine brings migraine relief when used alone and when mixed with other migraine drugs. One study found 1,000 mg acetaminophen plus 130 mg caffeine worked as well as sumatriptan 50 mg to treat acute migraine. Both had similar side effects, which were mild or moderate. Doctors believe this means acetaminophen with caffeine may be a good option for people who cannot take triptans.3

    Some over-the-counter cold medicines and diuretics also contain caffeine. Diuretics are drugs that cause your body to release more water and salt.2

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