Caffeinated Coffee May Reduce The Risk Of Cancers Of The Oral Cavity
Head and neck cancers originate in the tissues in or around the mouth, nose, and throat. Risk factors for head and neck cancer include smoking, alcohol consumption, and infection with high-risk types of human papilloma virus .
To evaluate the relationship between coffee and tea consumption and risk of head and neck cancer, researchers combined information from previous studies. These studies included a total of 5,139 people with cancer and 9,028 people without cancer.
- Compared with people who didnt drink coffee, people who drank four or more cups of caffeinated coffee per day were 39% less likely to have cancer of the oral cavity or pharynx. Caffeinated coffee did not affect risk of laryngeal cancer.
- Consumption of decaffeinated coffee was less common, and the effects on head and neck cancer risk remain uncertain.
- Tea intake did not affect risk of head and neck cancer.
These results do not conclusively prove that coffee reduces the risk of head and neck cancer. Factors other than coffee intake could explain the difference in cancer risk. Nevertheless, if confirmed, these results suggest that coffee may provide a benefit.10
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Overall, 77% of women who have triplenegativebreastcancer are alive five years after diagnosis. Is triple-negativebreastcancer worse? Triple-negativebreastcancer is usually more aggressive, harder to treat, and more likely to come back than cancers that are hormone receptor-positive or HER2-positive. Triple Negative Breast Cancer Day is the only global event dedicated to raising both awareness and funds exclusively for triple negative breast cancer. Find out how you can get involved! Ask friends to leave their jumbo latte or favorite coffee drink behind for a week and donate the $35 saved to make a difference in the TNBC Foundations. Breast cancer survival was not greater among participants who were high consumers of coffee and had IR-positive breast cancer or those with HER2-enriched or basal-like/triplenegativebreast. Overall, 77% of women who have triplenegativebreastcancer are alive five years after diagnosis. Is triple-negativebreastcancer worse? Triple-negativebreastcancer is usually more aggressive, harder to treat, and more likely to come back than cancers that are hormone receptor-positive or HER2-positive. Medications. For breast pain or tenderness, your doctor may suggest aspirin, Tylenol, or ibuprofen. A mild water pill, also called a diuretic, can help.
Acc2 Enzyme And Survival Rates
From patient data, the researchers also determined that low levels of activation of the gene that makes the ACC2 enzyme, which normally restricts fatty acid oxidation, was associated with worse survival in breast cancer patients, especially those with triple-negative breast cancer.
The researchers transplanted human triple-negative breast tumor tissue into the mammary glands of mice, allowed the tumors to grow, and then injected the mice with etomoxir. Tumor growth was dramatically slowed by etomoxir treatment, and fewer metabolites associated with fat oxidation were produced. The treatment was not effective, however, in triple-negative tumors with low levels of MYC, indicating that high MYC expression combined with low levels of ACC2 may point to a subclass of triple-negative tumors that are vulnerable to inhibitors of fatty acid oxidation, the scientists concluded.
This is very promising, but there is quite a bit more research to do before we can try this approach in humans, Goga said. Our goal is to try to identify fatty acid oxidation inhibitors and to ascertain which are likely to be most efficacious against these cancers, with the goal of bringing one to the clinic. It may be possible to repurpose drugs that already have been developed.
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Does Coffee Consumption Improve Survival In Advanced Colorectal Cancer
A large observational study strongly suggests that increased coffee consumption among patients with advanced or metastatic colorectal cancer may be associated with reduced risk for disease progression and death.
In the trial 1171 patients with advanced or metastatic CRC being treated with chemotherapy were allowed to enroll in an optional diet and lifestyle study that collected data between 2005 and 2018. Participants responded to a series of semiquantitative food frequency questionnaire that assessed 131 food items and supplements.
The data suggested that for every cup of coffee per day there was an improvement in overall survival. This appeared independent of caffeine. Compared with coffee abstainers, those who drank at least 2 cups of decaffeinated coffee had an improved risk for overall survival as well.18
Caffeine And Breast Cancer Risk
Caffeine consumption has been associated with a decreased risk of breast cancer in a few studies, though the results have been inconsistent. Furthermore, more research is needed into the reason for the possible link, as well as the timing and amount of caffeine that could potentially have any effect on breast cancer.
One group of researchers in Italy examined 21 studies on this subject but were unable to find a clear relationship between caffeine consumption and the risk of breast cancer. However, drinking four cups of coffee per day was associated with a 10% reduction for postmenopausal women.
A Swedish study found that coffee consumption was associated with a slightly decreased breast cancer risk, and tea consumption was associated with an increased risk of breast cancer.
Researchers who conducted a large multinational trial also suggested that a higher intake of caffeinated coffee is associated with a lower risk of breast cancer in postmenopausal women, while decaffeinated coffee was not associated with any impact.
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Why Is This Study Important
Many people regularly drink coffee and tea. This study finds that these beverages are not harmful and may be linked to a lower risk of death after a breast cancer diagnosis. For breast cancer survivors who are concerned with how diet affects their chance of cancer returning, this study adds some clarity to one part of daily life.
Postmenopausal Women Who Drink Coffee Have A Statistically Significant Reduced Risk Of Developing Estrogen Receptor
It turns out that coffee drinkers have a lower incidence of breast cancer overall than those who abstain however, when researchers really dug into the correlation and corrected for other lifestyle factorssuch as weight, level of physical activity, family history, and age at menopausethe protective effect of coffee was only measurable for ER-negative breast cancer. The results of the study showed a modest decrease in overall breast cancer risk and a significant reduction in the risk of ER-negative breast cancer.
This doesnt mean that postmenopausal women who want to avoid breast cancer need only to slurp coffee to avoid the disease. What it means is that if you tend to avoid indulging in coffee based on the perception that it could harm your healthyou may be able to enjoy this simple pleasure without the extra helping of guilt.
Its still important to maintain a healthy weight, stay physically active, eat a nutrient-dense diet, and avoid smoking however, if you do all those things and still want to enjoy your morning cup of coffee, it appears that you can do so without worry. The bottom linebalance is always best.1
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Do I Need Genetic Counseling And Testing
Your doctor may recommend that you see a genetic counselor. Thats someone who talks to you about any history of cancer in your family to find out if you have a higher risk for getting breast cancer. For example, people of Ashkenazi Jewish heritage have a higher risk of inherited genetic changes that may cause breast cancers, including triple-negative breast cancer. The counselor may recommend that you get a genetic test.
If you have a higher risk of getting breast cancer, your doctor may talk about ways to manage your risk. You may also have a higher risk of getting other cancers such as ovarian cancer, and your family may have a higher risk. Thats something you would talk with the genetic counselor about.
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Cell Viability With Different Treatments
To test whether caffeine, cisplatin or the combination of both induced cell death with the triple-negative breast cancer cell line , estrogen-receptor lacking breast cancer line and normal breast epithelial cell line , cell viability was examined by trypan blue exclusion. There is a statistical significance between the control and caffeine and cisplatin combination treatment for the MDA-MB-231 cells, which decreased in the cell survival rate . None of the treatments caused significant cell death within MCF7 cells or MCF10A cells. This demonstrates that the combination treatment with caffeine enhances the effectiveness of cisplatin for targeting triple negative breast cancer cells without perturbing normal epithelial breast cells.
Cell viability assay demonstrates the cell survival rate for each treatment with MDA-MB-231, MCF7 and MCF10A cell lines. Star indicates a significant difference with p-value < 0.05.
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A Little Coffee Doesnt Hurt And Might Help Reduce Your Cancer Risk
- Original: Oct 24, 2020
Coffee reduces the risk of some cancers, prolong survival of others and does not appear to increase risk of any cancer.
If youre a slave to your morning cup of coffee research shows that you dont necessarily need to hang up the habit just yet. In fact according to an analyses published in the New England Journal of Medicine reviewing all publications on the topic the data shows that coffee may reduce the risk of many cancers and isn’t associated with any specific cancer risk. Coffee contains hundreds of different compounds, some of which may have anticancer effects. Nevertheless, the exact mechanisms by which coffee may impact cancer risk are not well understood.16 So what do the studies show?
High Rates Of Glucose Metabolism In Tumors
Researchers have focused attention on abnormally high rates of glucose metabolism in tumors, first discovered nearly a century ago. However, for the new Nature Medicine study the scientists used a technique called mass spectrometry to identify metabolites associated with triple-negative breast tumors that arose in mice when MYC expression was abnormally elevated. In collaboration with the research group of Daniel K. Nomura, PhD, associate professor of chemistry and of nutritional sciences and toxicology at UC Berkeley, they found an unusual abundance of fatty acid oxidation metabolites, indicating that triple-negative breast cancer cells may be oxidizing fat to satisfy their energy needs.
In addition to studying these transgenic mice that had a switchable MYC gene, the researchers worked with human tumor tissue, with clinical data from The Cancer Genome Atlas and other public databases, and with tumor cells growing in the lab. UCSF graduate student Roman Camarda designed and conducted most of the experiments and wrote up the study for publication.
In triple-negative breast cancer cells with increased MYC activity grown in the lab, etomoxir inhibited production of the molecule ATP, the common energy currency of cells, but did not have the same effect on other types of breast cancer cells.
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Peaches Apples And Pears
Fruits specifically peaches, apples, and pears have been shown to safeguard against breast cancer.
In a study in 75,929 women, those who consumed at least 2 servings of peaches per week had up to a 41% reduced risk of developing ER breast cancer .
Interestingly, a test-tube study revealed that polyphenol antioxidants from peaches inhibited the growth and spread of a breast cancer cell line .
Furthermore, a study analyzing data from 272,098 women linked apple and pear intake to a lower risk of breast cancer ” rel=”nofollow”> Share on Pinterest
Beans are loaded with fiber, vitamins, and minerals. Specifically, their high fiber content may protect against breast cancer.
A study in 2,571 women found that high bean intake reduced breast cancer risk by up to 20%, compared with low bean intake .
Additionally, in a study in 1,260 Nigerian women, those with the highest intake of beans had up to a 28% reduced risk of breast cancer, compared with those with the lowest intake .
Can Caffeine Affect Breast Cancer Outcomes
A 2021 study suggests that coffee may improve breast cancer survival, according to the American Institute for Cancer Research. People drinking more than three cups of coffee a day had a 25% lower risk of dying from breast cancer compared with those who abstained from coffee.
People drinking three cups of tea daily after a breast cancer diagnosis had a 26% lower risk of dying from any cause compared with people who did not drink tea.
Other factors that impacted survival included breast cancer treatment, body mass index , and physical activity.
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Green Tea And Breast Cancer Recurrence
Many people who have had breast cancer worry about the risk of recurrence. While there is no solid evidence of coffee intake and breast cancer recurrence risk, the caffeinated beverage green tea might be an option to consider.
Green tea consumption has been demonstrated to have anti-cancer properties, and it appears to reduce the risk of late recurrence of breast cancer .
The right amount or maximum amount of caffeine differs for everyone, but it can range from one to five servings of a caffeinated beverage or food per day.
Study Suggests Coffee May Improve Survival After Breast Cancer
Mya Nelson
Mya R. Nelson is a science writer for American Institute for Cancer Research.
New research suggests that drinking coffee after breast cancer treatment may improve survival. The study, funded by AICR, adds to a growing body of research on how diet affects breast cancer survivors health.
The study was published in the British Journal of Cancer.
When it comes to cancer research, coffee lovers have had plenty of good news in recent years. AICRs evaluation of the global research found strong evidence that coffee protects against both liver and endometrial cancers. Other research has suggested coffee may lengthen survival.
But few studies have focused on how this popular beverage may affect breast cancer survival. These studies have been relatively small and given inconsistent findings.
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Coffee Cuts Risk Of Liver Cancer
Research has found that regular coffee consumption can reduce the risk of liver cancer by 40 percent. In fact, the study published in Clinical Gastroenterology and Hepatology, found that people who consume more than three cups of coffee per day reduce their risk by more than 50 percent.4
Researchers conducted a meta-analysis of data collected between 1996 and 2012 and then selected 16 studies that involved a total of 3,153 liver cancer cases. They included data on 900 more recent cases of HCC published since their last detailed study from 2007.5
They found that individuals who consume any amount of coffee have a 40 percent reduced risk of HCC compared to those who drink no coffee. Whats more, the higher the consumption, the more the risk was reduced. Those who drank more than three cups per day had a 50 percent or more reduced risk. The association between coffee and reduced risk was consistent regardless of gender, alcohol consumption, or history of hepatitis or liver disease.
The researchers concluded that coffee appears to reduce the risk of liver cancer. They speculate that it might affect liver enzymes and the development of cirrhosis and therefore, could protect against liver cancer.
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Oestrogen, progesterone, and HER2 These are the three substances behind triple-negative. Oestrogen & progesterone are hormones. Some of our cells have receptors that these hormones attach to, and fuel them. Some breastcancer cells may not have these receptors .
Triplenegativebreastcancer is a subtype of breastcancer characterized by the lack of estrogen receptors, progesterone receptors and over-expression of the human epidermal growth factor receptor 2, limiting targeted treatment.
She was advised to take black cumin seeds with honey three times a day, in addition to garlic and honey. After three months, her cancer completely disappeared. The woman continued consumption of these nutrient-rich foods even after illness had diminished.. As a conclusion, this woman cured cancer with 2 natural mixtures.
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My doctors told me I had triplenegativebreastcancer, a fast-growing, aggressive kind of breastcancer which the oncologists describe as tricky. About 10-15 percent of breastcancers are.
breastcancer incidence is higher in young AAW compared to CW such that 30-40% of AAW with breastcancer are under age 50 when diagnosed compared to just 20% of CW . In addition, the five-year survival rate for AAW is significantly lower than for CW . Triplenegativebreastcancer is defined as tumors that do not express the estrogen or progesterone receptors or HER2. TNBC.
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Combining Caffeine With Traditional Therapy
There are many factors at play when it comes to the relationship between coffee and breast cancer, and its effects when combined with cancer treatment have begun to be examined.
Caffeine has antioxidant and anti-inflammatory functions. Antioxidants counteract oxidationa chemical process that leads to cancer and heart disease. Inflammation worsens many different diseases, including cancer.
- A 2020 study showed that caffeine combined with the chemotherapy drug cisplatin in a laboratory setting increased the effect of cisplatin on triple-negative breast cancer cells. Triple-negative breast cancer is highly aggressive due to the absence of hormone receptors.
- Another study noted that women who consumed high amounts of caffeine and were treated with tamoxifen for breast cancer prevention were less likely to develop the condition. The researchers also evaluated the response of cancer cells to the caffeine in a laboratory setting and found that cell growth was suppressed in estrogen receptor-positive and estrogen receptor-negative samples. The researchers theorized that caffeine can make women more sensitive to the beneficial effects of the drug.
Because findings in laboratory experiments are not always the same when they are applied to humans, the effects of caffeine on breast cancer cells would have to be replicated in humans in a clinical trial before it would be accepted as a treatment for breast cancer.